The aging of the population worldwide strongly correlates with the rising number of the cognitive impairments, which account for appr. 15% of the global burden of disease (WHO, 2001). Around 25% of the population above age 65 suffer from dementia, among which Alzheimer plays a leading role. The global Alzheimer's epidemic currently affects 50 million people. It is estimated that ca. 150 million people will develop dementia by the year 2050. This will put an immense financial stress on the social system of appr. US$ 1.1 billion annually. Up till now there is no eligible strategy to cope with the global Alzheimer's epidemic.
Most sources of literature implicate that cognitive impairments strongly correlate with the neurodegenerative and cerebrovascular pathologies (Corriveau RA et al., 2016) with Alzheimer disease being the most prevalent example (appr. 65 % of cases). This knowledge lead to the development of several prevention strategies. The results of the long-term population studies clearly show that improvement in blood pressure control and vascular health reduces the age-specific incidence of dementia (Satizabal CL et. al, 2016).